Global sales




Top 25 drug companies by sales (2006)
Company Pharma sales
($ million)
Pfizer United States 45,083
GlaxoSmithKline United Kingdom/United States 40,156
Sanofi-Aventis France 38,555
Roche Switzerland 27,290
AstraZeneca United Kingdom 26,475
Johnson & Johnson United States 23,267
Novartis Switzerland 22,576
Merck & Co United States 20,375
Wyeth United States 16,884
Lilly United States 15,691
Bristol-Myers Squibb United States 13,861
Boehringer Ingelheim Germany 13,860
Amgen United States 13,858
Abbott Laboratories United States 12,395
Bayer Germany 10,162
Takeda Japan 8,716
Schering-Plough United States 8,561
Teva Israel/United States 7,821
Genentech United States 7,640
Astellas Japan 7,390
Novo Nordisk Denmark 7,087
Daiichi Sankyo Japan 6,790
Baxter International United States 6,461
Merck KGaA Germany 5,643
Eisai Japan 4,703

In 2011, global spending on prescription drugs topped $954 billion, even as growth slowed somewhat in Europe and North America. The United States accounts for more than a third of the global pharmaceutical market, with $340 billion in annual sales followed by the EU and Japan. Emerging markets such as China, Russia, South Korea and Mexico outpaced that market, growing a huge 81 percent.

The top ten best-selling drugs of 2013 totaled $75.6 billion in sales, with the anti-inflammatory drug Humira being the best-selling drug worldwide at $10.7 billion in sales. The second and third best selling were Enbrel and Remicade, respectively. The top three best-selling drugs in the United States in 2013 were Abilify ($6.3 billion,) Nexium ($6 billion) and Humira ($5.4 billion). The best-selling drug ever, Lipitor, averaged $13 billion annually and netted $141 billion total over its lifetime before Pfizer's patent expired in November 2011.

IMS Health publishes an analysis of trends expected in the pharmaceutical industry in 2007, including increasing profits in most sectors despite loss of some patents, and new 'blockbuster' drugs on the horizon.

Patents and genericsedit

Depending on a number of considerations, a company may apply for and be granted a patent for the drug, or the process of producing the drug, granting exclusivity rights typically for about 20 years. However, only after rigorous study and testing, which takes 10 to 15 years on average, will governmental authorities grant permission for the company to market and sell the drug. Patent protection enables the owner of the patent to recover the costs of research and development through high profit margins for the branded drug. When the patent protection for the drug expires, a generic drug is usually developed and sold by a competing company. The development and approval of generics is less expensive, allowing them to be sold at a lower price. Often the owner of the branded drug will introduce a generic version before the patent expires in order to get a head start in the generic market. Restructuring has therefore become routine, driven by the patent expiration of products launched during the industry's "golden era" in the 1990s and companies' failure to develop sufficient new blockbuster products to replace lost revenues.

Prescriptionsedit

In the U.S., the value of prescriptions increased over the period of 1995 to 2005 by 3.4 billion annually, a 61 percent increase. Retail sales of prescription drugs jumped 250 percent from $72 billion to $250 billion, while the average price of prescriptions more than doubled from $30 to $68.

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